From vasculature to single cells, 3D light-sheet imaging reveals the intricate architecture of a whole mouse brain in unparalleled detail.
3D imaging of mouse colorectal tumor stained with CD3, B220, and YoPro1 reveals tertiary lymphoid structures (TLS) in full spatial context.
3D fluorescence imaging of human lung tissue stained with Fast Green reveals collagen architecture for fibrosis and tissue remodeling research.
3D imaging of human skin biopsy stained with tryptase, TO-PRO-3, and PGP9.5 reveals mast cell–nerve interactions for dermatology and oncology research.
High-resolution 3D imaging of a cleared rabbit retina stained with TO-PRO-3 and eosin, preserving architecture across retinal, choroid, and scleral layers.
3D imaging of prostate organoids stained with TO-PRO-3 and eosin reveals spatial heterogeneity, cellular interactions, and microenvironmental detail.
High-resolution 3D imaging of a mouse pancreatic cyst stained with Ki67 and γ-H2AX reveals proliferation and DNA damage in full spatial context.
3D fluorescence imaging of prostate tissue stained with Fast Green reveals the collagen architecture, orientation, and density, providing insights beyond 2D histology.
High-resolution 3D imaging of human tonsil tissue stained with YO-PRO-1 for nuclei and tryptase for mast cells.
3D imaging of prostate organoids with LUMI shows ROI selection, multi-well scanning, and high-resolution analysis using TO-PRO-3 and eosin staining.
See the full Aurora Workflow in action with 3D imaging of murine heart vasculature, delivering vessel measurements, branching analysis, and cell counts.
LUMI (Light-Sheet User Microscope Interface) enhances HOTLS with effortless setup, live preview, and smart automation for seamless 3D imaging.
2 mm pig muscle section stained with CD31 and YO-PRO-1 imaged in 3D on Aurora HOTLS, revealing vascular networks with speed and precision.
FFPE colorectal tissue stained with YO-PRO-1 and anti-CD8 imaged in 3D at 2 μm/pixel on Aurora HOTLS. Quantification of CD8+ lymphocytes across whole section.
3D imaging of human placenta tissue stained with SMA, HLA-G, and CD31. From whole-tissue scans to single-cell resolution, uncover tissue complexity in detail.
Whole mouse brain imaged in 3D with TO-PRO-3 and eosin. Scout and Zoom workflows capture glioblastoma ROI, segmentation, and high-resolution morphology.
3D imaging of a whole murine heart stained with SMA reveals vascular structures and mural cells, from large vessels down to pericytes.
Scout 3D imaging of a human DRG sample from AnaBios with computational H&E staining, ToPro-3 for nuclei, and eosin for protein structures.
Zoomed 3D imaging of human DRG sample from AnaBios with computational H&E staining, ToPro-3 for nuclei, and eosin for protein structures.
3D imaging of cleared liver tissue stained with Collagen III, followed by segmentation analysis using a pixel classifier to highlight fibrosis.
3D spatial biology image of liver biopsy segmented with AI, highlighting fibrosis (cyan) and steatosis (yellow) for quantitative pathology insights.
A 3D fly-through of liver tissue stained with computational hematoxylin and eosin, showcasing structures beyond traditional 2D pathology.
3D imaging of human colon stained with Calretinin reveals dense innervation of the mucosa and submucosa.
A 3D scan of a human ileocecal sample with over 840 billion pixels and 2,350 mm³ volume, imaged on Alpenglow’s Aurora HOTLS platform.
Large cleared human brain slice (10 × 7 × 0.3 cm) imaged at 0.17 microns per pixel using the CUBIC protocol for high-resolution volumetric analysis.
3D imaging of cleared mouse fat pad reveals blood vessels, macrophages, and nerves labeled with lectin, CD68, and PGP9.5.
3D imaging of cleared tonsil tissue stained with anti-CD21 and TO-PRO-3 reveals B cell and follicular dendritic cell distribution in FFPE samples.
3D imaging of cleared tonsil tissue stained with anti-CD45RO (UCHL1) and TO-PRO-3 reveals memory T cell distribution in thick FFPE samples.
3D imaging of cleared tonsil tissue stained with anti-CD3 (BC33) and TO-PRO-3 reveals the distribution of T cells in thick FFPE samples on the Aurora HOTLS platform.
3D imaging of cleared tonsil tissue stained with anti-CD8 (SP6) and TO-PRO-3 reveals cytotoxic T cells in thick, FFPE samples imaged on the Aurora platform.
High-resolution 3D imaging of human tonsil reveals cytotoxic T cells and macrophages stained with CD8 and CD68, mapped in their native spatial context.
High-resolution 3D imaging of scalp epidermis reveals branching nerve structures and nuclear organization, advancing hair and dermatology research.
See hair follicles in true 3D, from bulb to dermal papilla, with detailed mapping of sensory nerves and nuclei for alopecia and hair research.High-resolution 3D imaging of scalp tissue reveals nuclei, immune cells, and nerve networks, driving new insights into alopecia and other skin diseases.
High-resolution 3D imaging of scalp tissue reveals nuclei, immune cells, and nerve networks, driving new insights into alopecia and other skin diseases.
High-resolution 3D imaging of atopic dermatitis reveals precise innervation and immune cell distribution, surpassing conventional histology.
High-resolution 3D imaging of CD45-stained skin biopsy shows lymphocyte clustering around nerves, offering new insights into immune cell behavior.
High-resolution 3D imaging of atopic dermatitis reveals lymphocyte clusters near nerves, stained with TO-PRO-3, PGP 9.5, and CD45. Explore detailed innervation and immune-cell interactions in lesional skin.
Journey through the delicate nerve structures of the epidermis and dermis at low resolution, and zoom in for an awe-inspiring close-up of lymphocyte distribution around these dynamic networks.
Low resolution image of a lesional Atopic Dermatitis sample stained with PGP9.5 (white) to highlight fine epidermal innervation, TO-PRO-3 (blue) for nuclear detail, and CD3 (green) to illuminate T-Cell infiltration of the Epidermis and Dermis.
40X image of a lesional Atopic Dermatitis samples stained with PGP9.5 (white) to highlight fine epidermal innervation, TO-PRO-3 (blue) for nuclear detail, and CD3 (green) to illuminate T-Cell infiltration of the Epidermis and Dermis.
In a Dynamk Capital interview, Alpenglow CEO Nick Reder, MD MPH, discusses 3D spatial biology, AI-powered analysis, and accelerating drug discovery.