This 3D dataset captures a section of the human placenta, showcasing its complex vascular architecture and cellular detail.

Smooth muscle actin (a-SMA, green) highlights the vasculature, while TO-PRO-3 (magenta) marks nuclei, creating vivid contrast that brings the tissue’s organization into focus.

Using Alpenglow Biosciences’ Aurora™ 3Di Hybrid Open Top Light Sheet microscope, this non-destructive approach preserves intact structure, free of slicing artifacts, and enables quantitative analysis.

The dataset provides valuable insights for reproductive biology, placental health, and maternal–fetal research, turning visually stunning imagery into decision-grade scientific data.