Real-World Applications of 3D Tissue Imaging
Explore real-world applications of AI-powered 3D tissue imaging, 3D histology, and digital pathology. Each use case shows how intact tissue imaging and spatial profiling with the Aurora™ 3D Spatial Biology Solution reveal biology that 2D slides can miss and how these insights support drug development and translational research.
3D imaging use cases across dermatology, immuno oncology, and more
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![Atopic Dermatitis Use Case]()
Atopic Dermatitis Use Case
See how 3D tissue imaging of full-thickness skin biopsies reveals immune–epithelial interactions, nerve fibers, and microvascular changes in atopic dermatitis. This use case highlights how 3D histology and spatial profiling can quantify inflammation patterns and treatment response across the entire lesion.
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![Promotional graphic for Alpenglow Biosciences on decoding immune-exclusion with 3D analysis, featuring colorful visual background and text about understanding lymphocytic patterns in tumors and improving immunotherapy.]()
Decoding Immune-Exclusion
This case study focuses on immune excluded tumors, using 3D tissue imaging and AI powered analysis to map lymphocyte patterns and exclusion zones across the whole tumor microenvironment. It illustrates how 3D spatial biology clarifies why some immunotherapies fail despite high target expression.
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![2D vs 3D Use Case]()
2D vs 3D Use Case
A side-by-side comparison of classic 2D histology versus 3D tissue imaging on the same specimen. This use case shows where 2D undercounts structures, misses rare events, or misrepresents tissue architecture, and how whole tissue 3D datasets provide a truer ground truth for digital pathology and AI models.
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![Image featuring a colorful microscopic view of lung tissue with text discussing spatial segmentation and analysis of lymphoid structures in non-small cell lung cancer using Alpenglow Biosciences technology.]()
Tertiary Lymphoid Structures in 3D
3D imaging of tertiary lymphoid structures in non-small cell lung cancer, with spatial segmentation and quantification of TLS size. This use case demonstrates how 3D histology supports TLS-based biomarkers and patient stratification in immuno-oncology.
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![Reveal Ground Truth in Immuno-Oncology]()
Reveal Ground Truth in Immuno-Oncology
A broader overview of how whole tissue 3D imaging, Aurora 3D workflows, and ground truth 3D data support immuno oncology programs.
Who are these 3D imaging use cases for
These use cases are designed for translational research teams, immuno-oncology scientists, dermatology and lung cancer programs, imaging core facilities, and AI groups evaluating 3D tissue imaging and digital pathology. Each example shows real datasets, workflows, and spatial readouts that can help you plan similar studies with the Aurora 3D platform or 3D histology imaging services.