3D Histology Imaging Services
Still using 2D tissue sections? You are missing the full story.
3D histology is non-destructive volumetric imaging of intact tissue blocks using light-sheet microscopy. It provides complete spatial context that cannot be obtained from thin 2D sections.
3D Dataset of H&E-Stained Liver Biopsy
What we do:
End-to-end 3D Histology Imaging Services
Full-service sample preparation for intact tissue imaging
Clearing, staining, and antibody optimization performed by our team to preserve tissue integrity and prepare samples for high-resolution 3D imaging. This enables reliable whole tissue imaging across diverse research applications in oncology, dermatology, immunology, and preclinical studies.
Whole tissue volumetric 3D imaging at multiscale resolution
Multiscale light-sheet imaging of intact tissues that produces gigabyte- to terabyte-scale 3D datasets with cellular-level detail. This delivers full volumetric context that cannot be captured in traditional 2D histology and supports advanced spatial profiling in large or heterogeneous samples.
Quantitative spatial analysis of tissue microenvironments
Comprehensive profiling of cells, vasculature, nerves, and tissue microenvironments to support drug delivery studies, mechanism validation, and translational research. Our scientists extract spatial metrics and volumetric insights that reveal interactions and patterns undetectable in thin sections.
What you get:
3D Data Deliverables and Quantitative Analysis Outputs
Intact Volumetric 3D Tissue Imaging
Non-destructive 3D histology that preserves tissue architecture and eliminates distortion from slicing or sectioning. This approach maintains true spatial relationships across the entire sample.
Cellular Resolution Volumetric Imaging
High-resolution fluorescence volumes that reveal structures, interactions, and spatial patterns not visible in 2D slides. Each dataset provides a complete tissue-scale context for accurate interpretation and downstream analysis.
Quantitative 3D Analysis Outputs
Clean 3D volumes, interactive visualization, and quantitative spatial metrics generated by our analysis team and delivered in ready-to-use formats to support research decisions without requiring additional analysis work on your side.
The Power of 3D Tissue Imaging
See Biology as It Really Exists
Traditional 2D sectioning destroys spatial relationships and introduces artifacts. Our 3D approach preserves the complete biological architecture, revealing connections and structures that sectioning would miss entirely.
From cellular interactions to tissue-wide patterns, 3D imaging provides the context you need to understand complex biological systems.
3D Imaging of Human Lung Collagen Architecture
Comprehensive Service Portfolio
Custom Marker Optimization
We optimize markers of interest and provide full protocol transfer to ensure precise, reliable results tailored to your specific research questions.
Clinical Trial Support
Robust support for clinical trials with validated protocols and quality assurance.
Proof-of-Concept Design and Execution
From initial concept to validated results, we design and execute PoC studies that demonstrate feasibility and guide your research direction.
3D Image Analysis and Quantification
Advanced analysis capabilities deliver in-depth insights and quantitative data, empowering your projects with cutting-edge technology.
Why 3D Histology is Different from 2D Slides
Traditional 2D Limitations
Destroys spatial relationships
Introduces sectioning artifacts
Samples only thin slices
Misses critical connections
Tissue is not preserved
3D Imaging Advantages
Preserves complete architecture
No distortion or artifacts
Full-volume data capture
Reveals true spatial context
Streamlined workflow
3D Imaging of Scalp Tissue
Our Expertise, Your Success
Expert Consultation
Work with specialists who understand both the technology and your research goals.
Custom Solutions
Tailored protocols and workflows designed specifically for your samples and questions.
Scalable Results
From pilot studies to large-scale projects, we scale with your research needs.
Applications of 3D Histology Imaging
Immune cell profiling, spatial organization, and neuroimmune interactions
Gastrointestinal, enteric, and organ-specific disease imaging
Drug distribution, penetration, and mechanism of action validation
Ready to See in 3D?
Transform your research with intact tissue imaging that reveals the full biological story. Our team of experts is ready to help you design and execute your next breakthrough study.
3D Computational H&E Imaging of TLS in NSCLC