Turn Tissue into Data with 3D Tissue Imaging and Spatial AI
Intact 3D tissue imaging, spatial profiling, and quantitative AI analysis in a single, end-to-end imaging platform.
Biology does not happen in sections.
Alpenglow transforms intact tissue into quantitative, analyzable 3D datasets.
By combining open-top light-sheet microscopy, scalable data infrastructure, and AI-powered analysis, Alpenglow preserves full tissue architecture while enabling cell-level measurement across entire specimens. The result is ground-truth spatial data that reveals biology and biomarkers that 2D sections routinely miss.
Mouse kidney captured as an intact 3D volume
Aurora 3D™: 3D Spatial Biology Platform for whole tissue imaging
End-to-end 3D imaging, data management, and AI analysis in one platform.
3Di™
Advanced 3D Tissue Imaging
The 3Di™ is a dual-path open-top light-sheet microscope for whole-sample imaging and high-resolution imaging, operated via the LUMI interface.
3Dm™
Automated 3D Data Management
3Dm™ aligns, organizes, and serves large volumetric datasets, ready for analysis and review.
3Dai™
AI-Powered 3D Image Analysis
3Dai™ quantifies cells, structures, and spatial patterns for cell-level spatial measurements.
3D imaging solutions by role
Find the right 3D tissue workflow for your research goal.
-
Reveal the full structure of skin in 3D. Alpenglow empowers dermatology researchers to analyze tumor margins, vessels, and inflammation with clarity.
-
Alpenglow helps immunologists decode the tissue microenvironment in 3D, revealing immune infiltration, spatial relationships, and treatment response.
-
From biodistribution to mechanism of action, Alpenglow’s 3D imaging platform gives translational scientists the clarity needed to drive better therapeutic decisions.
-
Simplify whole-tissue imaging and accelerate user workflows. The 3Di HOTLS microscope combines speed, clarity, and accessibility, ideal for any imaging facility.
-
Alpenglow helps group leaders deliver faster, deeper insights with 3D imaging, replacing slicing with full-volume clarity and reproducible data.
-
Alpenglow helps pathologists move beyond flat slides, offering 3D views of intact tissue to reveal margins, patterns, and structures missed in 2D.
3D Tissue Imaging applications across tissues
Whole tissue 3D imaging and AI powered analysis uncover spatial insights across dermatology, immuno oncology, neuroscience, and translational research.
Dermatology
The 3D Derm Score Assay™ visualizes intact skin architecture in 3D, mapping nerves, immune cells, and inflammation across the full tissue depth.
Immuno-Oncology
The 3D I/O Pro Assay™ characterizes tumor-immune interactions in 3D, revealing immune infiltration and stromal organization within the microenvironment.
Multi-Field Capabilities
A flexible 3D platform for neuroscience, immunology, and translational studies — enabling volumetric mapping of complex tissue biology.
Ground-Truth 3D Data: See What You’ve Been Missing
Alpenglow captures whole tissues intact in 3D, revealing architecture and cellular context with full-volume readouts clarity that conventional slides cannot provide. Our approach preserves true 3D tissue structure across volumes, enabling accurate measurement of cell populations and distances.
Alpenglow Biosciences in the News
Leading partnerships and innovations advancing the future of 3D spatial biology and AI-enabled diagnostics.
Meet Alpenglow Biosciences
Connect with the team behind decision-ready 3D spatial biology. See where to meet us next.
About Alpenglow Biosciences
Alpenglow Biosciences accelerates drug development and improves clinical diagnostics through AI-enabled 3D tissue imaging and digital pathology. The Aurora 3D spatial biology platform digitizes intact tissue samples, delivering quantitative 3D datasets while preserving tissue for molecular analysis.
Discover New Biology
Uncover insights in intact tissue that 2D methods miss
Support AI Development
Build models with ground truth 3D data
Generate Volumetric Datasets
Create analysis-ready 3D data and spatial metrics
Improve Decision-Making
Enhance outcomes in preclinical and clinical programs
Five of the top 10 pharmaceutical companies collaborate with Alpenglow to uncover new insights, streamline timelines, and improve success rates across their pipelines.
Transform Your Research with 3D Spatial Biology
Ready to see what your tissue looks like in 3D?
Send a sample, evaluate 3Di HOTLS, or explore Summit AI analysis with the Alpenglow team.
Join our Newsletter
Hear the latest news from 3D Spatial Biology and how we are revolutionizing the world of pathology.