Computational H&E staining combined with non-destructive 3D imaging reveals the true complexity of tertiary lymphoid structures (TLS) in NSCLC. Unlike thin 2D sections that risk misclassification, Alpenglow’s 3Di platform captures entire TLS morphology, volume, and cellular composition, delivering accurate insights into immune architecture and tumor context.
3D segmentation of prostate glands using synthetic CK8 immunofluorescence derived from fluorescent H&E analogues. By combining image-translation models with traditional computer-vision methods, researchers achieved whole-biopsy 3D gland segmentation without manual labeling.
From vasculature to single cells, 3D light-sheet imaging reveals the intricate architecture of a whole mouse brain in unparalleled detail.
3D imaging of prostate organoids stained with TO-PRO-3 and eosin reveals spatial heterogeneity, cellular interactions, and microenvironmental detail.
3D imaging of prostate organoids with LUMI shows ROI selection, multi-well scanning, and high-resolution analysis using TO-PRO-3 and eosin staining.
See the full Aurora Workflow in action with 3D imaging of murine heart vasculature, delivering vessel measurements, branching analysis, and cell counts.
LUMI (Light-Sheet User Microscope Interface) enhances HOTLS with effortless setup, live preview, and smart automation for seamless 3D imaging.
In a Dynamk Capital interview, Alpenglow CEO Nick Reder, MD MPH, discusses 3D spatial biology, AI-powered analysis, and accelerating drug discovery.