AI-Driven 3D Tissue Imaging Across Research Fields
Multi field 3D tissue imaging capabilities across research areas
Aurora 3D Platform enables AI-powered 3D tissue imaging across multiple research fields. The same platform and 3D histology imaging workflows can be applied to dermatology, lung, gastrointestinal, immuno-oncology, and vascular biology. This page summarizes example indications, tissue inputs, and quantitative analytics for each field, showing how one 3D tissue imaging platform supports diverse programs.
You can adapt panels, markers, and analysis pipelines to new indications while preserving a consistent 3D workflow.
Alpenglow Biosciences applies 3D tissue imaging and AI-powered analysis to inflammatory and immune-mediated skin diseases, focusing on nerve-immune interactions and skin architecture.
Indications
Hidradenitis Suppurativa (HS)
Chronic Spontaneous Urticaria (CSU)
Tissue Inputs
FFPE Skin Punch Biopsies
Freshly Fixed Tissues
Fresh, fixed or frozen skin samples
Analytics (examples)
3D Immuno-Oncology Profiling
The multi-field capabilities of Aurora™ 3D include immuno-oncology profiling across solid tumors, complementing the dedicated 3D immuno-oncology assays.
Indications
Tissue Inputs
Tumor Biopsies
Resected Tumor Material
Fresh, Frozen, or FFPE tumor samples
Analytics (examples)
TIL tumor/TIL stroma ratio
% tumor or tumor volume
Immune cell phenotypes and spatial distribution
3D gastrointestinal tissue imaging
3D gastrointestinal imaging captures villi, crypts, mucosal architecture, and innervation in a single volume, supporting studies in intestinal disease.
Indications
Tissue Inputs
Large resected gastrointestinal specimens
Colonoscopy or endoscopy biopsies
Fresh, frozen, or FFPE GI tissues
Analytics (examples)
Villus height to crypt depth ratios
Mucosal thickness and architecture
Innervation patterns in the intestinal wall
3D lung tissue imaging
3D lung imaging reveals fibrosis patterns, airway structure, and immune infiltration across the full tissue volume, which can be difficult to appreciate in 2D.
Indications
Idiopathic Pulmonary Fibrosis (IPF)
Chronic Obstructive Pulmonary Disease (COPD)
Tissue Inputs
Lung Bronchial Biopsies
Resected Material
Fresh, Frozen or FFPE
Analytics (examples)
3D vascular and angiogenesis imaging
3D imaging of vasculature captures vessels, branching patterns, and relationships to surrounding tissue, enabling quantitative vascular analysis.
Indications
Tissue Inputs
Tissue-Specific Biopsies
Resected heart, tumor, or placental tissue
Fresh, Frozen or FFPE samples
Analytics (examples)
Cell count within and around vessels
Vessel dimensions, for example, diameter and length
Distance Measurements between vessels and other structures
Branching Patterns and Vascular Network Complexity
Explore more 3D tissue imaging use cases
Multi-field 3D tissue imaging capabilities extend beyond the examples listed above. Aurora™ 3D and Alpenglow’s 3D histology imaging services can be adapted to additional organs, disease areas, and models.