High-resolution (40X) 3D imaging with Hybrid Open Top Light Sheet (HOTLS) microscopy of a Region of Interest in a lesional Atopic Dermatitis skin punch biopsy reveals intact tissue architecture and spatial immune organization.

The sample was stained with TO-PRO-3 for nuclei, PGP9.5 for nerve fibers, and CD3 for T cells, enabling detailed visualization of neuro-immune interactions and inflammatory pathways.

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Image reproduced with permission from Incyte Corporation.