Molecular Instruments and Alpenglow Biosciences Partner to Advance 3D RNA Imaging and Launch the 3D Imaging World Cup 2025

Molecular Instruments (MI), creators of the innovative HCR™ platform, and Alpenglow Biosciences, developers of the 3Di™ Hybrid Open-Top Light-Sheet (HOTLS) microscopy system, have announced a strategic partnership to enable high-resolution, three-dimensional RNA imaging in intact tissues, organoids, embryos, and other complex biological specimens—without the need for physical sectioning.

“We are excited to work with the team at Molecular Instruments,” said Nicholas Reder, MD, CEO of Alpenglow Biosciences. “With their high-quality HCR™ Gold reagents and deep-tissue penetration capabilities, combined with our 3Di™ Instrument, we offer researchers a powerful solution to visualize RNA targets throughout intact samples.”

Why This Partnership Matters

• High Signal, Low Background:
  Molecular Instruments’ amplification reagents are optimized for deep tissue penetration and minimal background, delivering clear, reliable RNA-FISH results across large or dense samples.

• Whole-Tissue 3D Imaging at Scale:
  Alpenglow’s 3Di™ HOTLS microscope captures intact tissue volumes up to 12.5 cm × 7 cm × 1 cm—ideal for organs, biopsies, and large experimental samples.

• Integrated AI Analysis:
  Alpenglow’s pipeline includes AI-powered analysis and data processing tools to accelerate insights from high-dimensional datasets, removing the burden of manual annotation and stitching.

• Workflow Compatibility:
  The system supports tissue clearing protocols, robotics integration, and scalable study designs for fields including oncology, neuroscience, immunology, and developmental biology.

Read the full press release on Businesswire

Launching the 3D Imaging World Cup 2025

To celebrate this collaboration, MI and Alpenglow have also announced the 3D Imaging World Cup 2025—a global competition inviting researchers to showcase their most compelling light-sheet datasets. Learn more on the official page: https://www.alpenglowbiosciences.com/3d-imaging-world-cup-2025

Learn more

HCR™ Gold RNA-FISH: molecularinstruments.com

3Di™ HOTLS microscopy & AI-driven analysis: alpenglowbiosciences.com