Skin is one of the most structurally complex organs in the body, where cellular organization, nerve networks, and tissue architecture interact across depth. Understanding these relationships requires imaging approaches that preserve the full spatial context of the tissue.

This dataset shows mouse skin tissue imaged in 3D, stained with Yo-Pro-1 to label nuclei and PGP9.5 to visualize peripheral nerves. The volumetric dataset reveals the intricate neural architecture within the dermis, where larger nerve bundles branch into progressively finer projections that extend throughout the tissue.