At SID 2026, Alpenglow Biosciences presents new data demonstrating how AI-powered 3D tissue imaging enables spatial profiling of neuroimmune organization across skin diseases.
Understanding disease in the skin requires more than isolated sections. It requires full-tissue context, where immune cells, nerve fibers, and structural features can be measured together across the entire biopsy.
Using Hybrid Open Top Light Sheet (HOTLS) microscopy combined with AI analysis, these studies capture intact tissue architecture and generate quantitative readouts that reflect how biology is organized in three dimensions.
The presentations highlight two key applications:
Hidradenitis suppurativa
Spatial characterization of mast cells and nerve fibers across full tissue samples reveals how neuroimmune interactions are organized within complex lesion architecture. These patterns are difficult to resolve with traditional 2D histology, where critical spatial relationships are lost.
Burning mouth syndrome
A pilot study applying 3D imaging to characterize tissue features associated with disease, exploring how volumetric imaging can uncover patterns not visible in standard pathology workflows.
Together, this work demonstrates how 3D histology enables:
Whole tissue imaging without destructive sectioning
Quantitative tissue analysis across intact samples
Spatial profiling of immune and neural networks
Identification of disease-relevant patterns in full context
Poster Presentations
Two poster presentations highlight this approach:
LB1098
A pilot study utilizing 3D imaging to characterize burning mouth syndrome, with the University of Utah
Poster Session
Friday, May 15, 2026, 4:30 pm – 6:00 pm
0088
Spatial characterization of mast cells and nerve fibers in hidradenitis suppurativa using hybrid open-top light-sheet microscopy, with the University of Minnesota
Poster Session
Friday, May 15, 2026, 4:30 pm
Scientific Session
The latest work will also be presented during the scientific session organized by the HS Foundation:
Session details
Date: Thursday, May 14
Time: 7:00 am – 8:15 am
Location: Marquette, 3rd Floor