Aurora Platform used in 3D airway tissue studies presented at COSM 2026
Recent work presented at COSM 2026 demonstrates the application of the Aurora Platform for integrated 3D tissue imaging and molecular analysis in airway disease.
The studies, presented by Shikhar Dhingra, MS, Medical Student at the University of Illinois Chicago and former Alpenglow Biosciences employee, focus on subglottic stenosis and combine three-dimensional imaging with RNA Fluorescence In Situ Hybridization (RNA-FISH) to analyze tissue organization across full biopsy volumes.
Two presentations highlight this approach:
• Poster (ABEA046)
Feasibility of RNA Fluorescence In Situ Hybridization (RNA-FISH) for three-dimensional molecular analysis of subglottic stenosis tissue
• Podium presentation (ALA #26-0056)
Novel 3D imaging protocol for visualizing collagen architecture in subglottic stenosis
Using the Aurora Platform, these studies enable:
• mapping of gene expression within intact tissue architecture
• visualization of collagen organization across full biopsy structure
• quantitative analysis of spatial relationships between molecular signals and tissue morphology
By combining 3D tissue imaging with RNA-FISH, the Aurora Platform supports a more complete characterization of airway tissue organization and remodeling, capturing spatial context that is difficult to assess with section-based approaches.
