3D imaging of mouse kidney

3rd Annual 3D Spatial Biology Summit

Ground-truth spatial biology. From intact tissue to predictive insight.

March 11th

AC Hotel San Francisco Airport /Oyster Point Waterfront San Francisco, CA

Why 3D Spatial Biology Matters

Biology is three-dimensional, yet most workflows still rely on flattened views. This meeting brings together leaders in imaging, spatial biology, computation, and translation to demonstrate how intact-tissue measurements provide ground-truth context and enable more predictive insights across research and development.

3D imaging of prostate organoids with LUMI shows ROI selection, multi-well scanning, and high-resolution analysis using TO-PRO-3 and eosin staining.

Conference Tracks

Three focused tracks explore the full spectrum of 3D spatial biology, from foundational imaging techniques to translational applications that drive clinical decisions.

Track 1: Seeing biology in full context

Intact tissue imaging as the foundation of spatial insight

How volumetric imaging reveals organization, gradients, and interactions that are lost in standard tissue sections.

Track 2: Molecular and computational layers in 3D

From spatial omics to AI informed by ground truth

Integrating RNA, protein, and imaging data with analysis methods that reflect tissue architecture.

Track 3: Translation and decision making

Turning 3D spatial data into scalable, predictive workflows

How 3D spatial data informs biomarkers, models, and clinical pipelines, including high-plex multi-omics.

NSCLC imaged in 3D with close up on TLS

Distinguished Keynote Speakers

Opening Keynote

Nils Gehlenborg, PhD

Associate Professor of Biomedical Informatics, Harvard Medical School

Closing Keynote

Jonathan Liu, PhD

Professor of Pathology and Professor, by courtesy, of Bioengineering, Stanford University

Invited Speakers

Andrew Song, PhD

Assistant Professor, Department of Translational Molecular Pathology, MD Anderson Cancer Center

Daniel Gomez, PhD

MR physicist and research scientist, Virdx

Kavita Sarin, MD, PhD

Professor of Dermatology, Stanford University

Suzanne M. Dintzis, MD, PhD, FCAP,

Professor of Laboratory Medicine and Pathology, University of Washington Medical Center

Eric Mörth, PhD

Fellow Specialist PostDoc, Harvard Medical School

Christopher Lowe, PhD

John B. and Jean De Nault Professor of Marine Science at the Hopkins Marine Station, Stanford University

Agenda

08:15 – 08:50 AM
Continental Breakfast

09:00 – 09:10 AM
Nick Reder, MD, MPH, CEO Alpenglow Biosciences, Inc.
Welcome and Introductions

09:10 – 10:00 AM
Opening Keynote Lecture
Nils Gehlenborg, PhD, Associate Professor, Biomedical Informatics, Harvard Medical School

10:05 – 10:35 AM
Kavita Sarin, MD, PhD, Professor of Dermatology, Director of the Skin Cancer Genetics Program, Stanford Cancer Institute

Skin as a sensor. Revealing hidden signals of disease

10:40 – 10:55 AM
Coffee Break

11:00 – 11:30 AM
Andrew Song, PhD, Assistant Professor, MD Anderson Cancer Center
Unlocking 3D molecular landscape with AI

11:35 – 12:05 PM
Daniel Gomez, PhD, MR Physicist and AI Research Scientist, Virdx
From three-dimensional histopathology to MRI contrast mechanisms in clinical imaging

12:10 – 01:00 PM
Lunch Break

01:05 – 01:35 PM
Christopher Lowe, PhD, John B. and Jean De Nault Professor of Marine Science at the Hopkins Marine Station, Stanford University

01:40 – 02:30 PM
Panel Discussion Nick Reder, MD, MPH | Nils Gehlenborg, PhD | Jonathan Liu, PhD | Suzanne Dintzis, MD
Exploring new frontiers in spatial biology using 3D tools

02:35 – 02:50 PM
Coffee Break

02:55 – 03:25 PM
Eric Moerth, PhD, Research Fellow in Biomedical Informatics, Harvard Medical School

3D Tissue Maps: Unlocking 3D context in spatial biology through interoperable and performant data formats and visual exploration tools 

03:30 – 04:10 PM
Closing Keynote Lecture
Jonathan Liu, PhD, Professor of Pathology and of Bioengineering, Stanford University
Non-destructive 3D pathology and analysis for clinical decision support

04:15 – 04:30 PM
Nick Reder, MD, MPH, CEO Alpenglow Biosciences, Inc.
Closing remarks

04:35 – 06:00 PM
Poster Cocktail Hour

Poster session: 3D Spatial biology in action

Posters will highlight how 3D spatial biology delivers ground-truth insight, from molecular mapping in intact tissue to computational, translational, and workflow applications.

Abstract submission format

  • Abstract length: up to 300 words

  • Structure: title, background, approach, key findings, implications

  • Previously presented work: allowed, if relevant and clearly contextualized

Important Details

A discount code for complimentary event registration will be issued to the first author of each submitted abstract.

A $250 recognition prize will be awarded to the Best Poster.

Submit your applications to: elisa@alpenglowbiosciences.com

Poster format: 36 X 48 inches

3D Imaging of blood vessels in human placenta

Who should attend

This meeting is designed for professionals and researchers working at the intersection of spatial biology, imaging, and computational analysis.

Biopharma Scientists

Discovery, translational research, pathology, and AI teams seeking ground-truth spatial insights

Biopharma researcher

Academic Researchers

Scientists working in imaging, spatial biology, and tissue mapping technologies

3D analysis

Computational Teams

Data scientists analyzing spatial or imaging-based datasets with AI and machine learning

Computational scientist

Event Location & Venue

AC Hotel San Francisco Airport / Oyster Point Waterfront

Located in the heart of San Francisco's biotech corridor, our venue offers convenient access to the airport and nearby research and industry hubs.

The waterfront setting provides an inspiring backdrop for networking and collaboration among spatial biology leaders.

 

Join the Future of Spatial Biology

When biology is measured in its full spatial context, interpretation becomes clearer and predictions become stronger. This symposium focuses on what becomes possible when intact tissue data is treated as ground truth.